![]() ![]() Applying the rules of effects of sample diluents and sample matrices can improve method sensitivity and accuracy, and avoid interferences as well. 80C), to reduce the viscosity, and it is normal practice to add salts to try and suppress interactions. Work with these solvents is carried out at raised temperatures (e.g. The tendencies and magnitudes of matrix effects were mainly dependent on the polarities of analyte solvents, diluents, and samples and were further affected by sample solvation processes. Polar polymers normally require the use of polar solvents such as dimethylformamide (DMF), dimethylsulfoxide (DMSO), N-methylpyrrolydine (NMP) or dimethylacetamide (DMAC). As sample amounts increased, analyte solvents exhibited various positive or negative matrix effects. The tendencies and magnitudes of diluent effects were mainly dependent on the polarities of analyte solvents and diluents. in organic solvents was independent of the polarity of the solvents but. From DMS to DMA, diluent effects were approximately linearly proportional to the values of solvent polarity relative to DMS. MeOH, DMF, DMA, NMP, DMSO, and HMPA was examined in HFIP, sulfolane, TMP. The results showed that analyte solvents with polarities higher than those diluents had higher peak responses in DMA or DMF than they had in DMS, and vice versa. Abstract : The effects of sample diluents, including Dimethyl sulfoxide (DMS), N,N-dimethylacetamide (DMA), and N,N-dimethylformamide (DMF), and the effects of sample matrices of a drug substance on 16 residual analyte solvents were studied using static headspace gas chromatography (HS-GC).
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